Toxic epidermal necrosis
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maqaarka lumay sifada Toxic epidermal necrosis
References
Stevens-Johnson Syndrome (SJS) iyo Toxic Epidermal Necrolysis (TEN) waa xaalado naadir ah halkaas oo maqaarku la kulmo necrosis ballaaran iyo daadinta. Marka la eego daaweynta, cyclosporine ayaa aad waxtar ugu leh SJS, halka isku-darka immunoglobulin-ka xididka (IVIg) iyo corticosteroids ay si fiican ugu shaqeeyaan kiisaska SJS iyo TEN.
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases that are characterized by widespread epidermal necrosis and sloughing of skin. Regarding treatment, cyclosporine is the most effective therapy for the treatment of SJS, and a combination of intravenous immunoglobulin (IVIg) and corticosteroids is most effective for SJS/TEN overlap and TEN.
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases that are characterized by widespread epidermal necrosis and sloughing of skin. Regarding treatment, cyclosporine is the most effective therapy for the treatment of SJS, and a combination of intravenous immunoglobulin (IVIg) and corticosteroids is most effective for SJS/TEN overlap and TEN.
Toxic epidermal necrolysis (TEN) waa falcelin maqaarka ah oo halis ah oo ay sababaan dawooyinka qaarkood iyo dhaqdhaqaaqa habdhiska difaaca, taas oo keenta in aad u go'o lakabka sare ee maqaarka (epidermis) , oo saameeya in ka badan 30% oogada jidhka. TEN waxay leedahay heerka dhimashada in ka badan 20%, badanaa waxaa sabab u ah caabuqyada iyo dhibaatooyinka neefsashada. Joojinta daawada keenaysa falcelinta, bixinta daryeelka taageerada, iyo isticmaalka daawaynta dheeraadka ah waxay hagaajin kartaa natiijada. Daraasadihii ugu dambeeyay waxay muujiyeen in daawooyinka sida cyclosporine, buro necrosis factor alpha inhibitors, iyo isku-darka difaaca globulin ee xididada iyo corticosteroids ay caawin karaan, oo ku saleysan tijaabooyinka la kantaroolay ee la kala soocay iyo falanqaynta daraasado badan.
Toxic epidermal necrolysis (TEN) is a serious skin reaction caused by certain medications and immune system activity, resulting in large-scale detachment of the outer skin layer (epidermis), affecting more than 30% of the body's surface. TEN has a mortality rate of over 20%, often due to infections and breathing difficulties. Stopping the medication causing the reaction, providing supportive care, and using additional treatments can improve the outcome. Recent studies have shown that drugs like cyclosporine, tumor necrosis factor alpha inhibitors, and a combination of intravenous immune globulin and corticosteroids can be helpful, based on randomized controlled trials and analyses of multiple studies.
Toxic epidermal necrolysis (TEN) is a serious skin reaction caused by certain medications and immune system activity, resulting in large-scale detachment of the outer skin layer (epidermis), affecting more than 30% of the body's surface. TEN has a mortality rate of over 20%, often due to infections and breathing difficulties. Stopping the medication causing the reaction, providing supportive care, and using additional treatments can improve the outcome. Recent studies have shown that drugs like cyclosporine, tumor necrosis factor alpha inhibitors, and a combination of intravenous immune globulin and corticosteroids can be helpful, based on randomized controlled trials and analyses of multiple studies.
Recent Advances: There is improved understanding of pain and morbidity with regard to the type and frequency of dressing changes. More modern dressings, such as nanocrystalline, are currently favored as they may be kept in situ for longer periods. The most recent evidence on systemic agents, such as corticosteroids and cyclosporine, and novel treatments, are also discussed.
Sababta ugu badan waa daawooyinka qaarkood sida lamotrigine, carbamazepine, allopurinol, antibiyootiga sulfonamide, iyo nevirapine. Qodobbada khatarta ah waxaa ka mid ah HIV iyo lupus erythematosus ee habaysan. Daaweyntu waxay caadi ahaan ka dhacdaa cusbitaalka sida qaybta gubatay ama qaybta daryeelka degdegga ah.
○ Daawaynta
Kani waa cudur halis ah, markaa haddii ay bushimahaaga ama afkaaga ay saameeyaan ama maqaarkaagu dhufto, u tag dhakhtarkaaga sida ugu dhakhsaha badan.
Daawooyinka laga shakiyo waa in la joojiyo. (tusaale, antibiyootiga, dawooyinka caabuqa ee aan steroid ahayn)